The Bit Bucket: Digital Monoculture -- Tim is talking about his second or third major spyware incursion. The scary part about this is how quickly the spyware fiends attach onto the '0-day' scripting exploits and infect machines quickly. However, people can still avoid spyware in Windows -- Minimally I run firefox, turn down the javascript options, and don't download many extra applications.
On another note, I think he's right on the 'old house' analogy. Take a look here for more insight.
